A Case of X-Linked Moesin-Associated Immune Deficiency in a Pediatric Patient

Background: X-Linked Moesin-Associated Immune Deficiency (X-MAID) is a rare severe combined immunodeficiency (SCID) subtype that can present at any age due to its variability. Depending on severity, patients demonstrate failure to thrive, recurrent bacterial and viral infections, and increased susceptibility to varicella zoster. It has been characterized by marked lymphopenia with hypogammaglobulinemia and impaired T-cell migration and proliferation. Case Presentation: This is a report of a Cuban 7-year-old male with poor weight gain and facial dysmorphia. He had a history of recurrent bacterial gastrointestinal infections and pneumonia beginning at 4 months of age. He additionally had 4-6 upper respiratory tract and ear infections annually. While still living in Cuba, he was admitted for a profound EBV infection in the setting of significant leukopenia. A bone marrow biopsy confirmed no malignancy. After he moved to the United States, his laboratory work-up revealed marked leukopenia with low absolute neutrophil and lymphocyte count with low T and B cells, very low immunoglobulin levels IgG, IgA, and IgM, and poor vaccination responses to streptococcus pneumonia, varicella zoster, and SARS-CoV-2. Genetic testing revealed a missense pathogenic variant c.511C>T (p.Arg171Trp) in the moesin (MSN) gene associated with X-MAID. He was managed with Bactrim and acyclovir prophylaxis, and immunoglobulin replacement therapy, and considered for hematopoietic stem cell transplantation. Discussion(s): Diagnosis of X-MAID should be considered in patients with recurrent infections and profound lymphopenia. As with SCID, early diagnosis and intervention is of utmost importance to prevent morbidity and mortality. This case demonstrates the importance of genetic testing in identifying this disease as it may prompt an immunologist to consider HSCT if conservative management is suboptimal. In the current literature, HSCT appears promising, but the long-term outcomes have yet to be described.Copyright © 2023 Elsevier Inc.

COVID-19-Related Encephalitis in a Child with PIK3CD Defect

Introduction: COVID-19 related encephalitis has been reported in pediatric patients;however, there are no reports in patients with inborn errors of immunity (IEI). Activated PI3K Delta Syndrome (APDS) is a disease of immune dysregulation with immunodeficiency, autoimmunity, and abnormal lymphoproliferation resulting from autosomal dominant gain-offunction variants in PIK3CD or PIK3R1 genes. We investigate a family with APDS, one mother and three children, one of whom developed COVID-19 related encephalitis. Method(s): Patients were consented to an IRB-approved protocol at our institution. Medical records and detailed immunophenotyping were reviewed. Family members were sequenced for IEI with a targeted gene panel. Result(s): The index case is a 10-year-old female with a known pathogenic variant in PIK3CD (c.3061 G > A, p.Glu1021Lys), who contracted SARS-COV-2 despite one COVID-19 vaccination in the series. Her disease course included COVID-related encephalitis with cerebellitis and compression of the pons, resulting in lasting truncal ataxia and cerebellar mutism. At that time, the patient was not on immunoglobulin replacement therapy (IgRT), but was receiving Sirolimus. Besides the index case, 3 family members (2 brothers, 1 mother) also share the same PIK3CD variant with variable clinical and immunological phenotypes. All children exhibited high transitional B-cells, consistent with developmental block to follicular B cell stage. Increased non-class switched IgM+ memory B cells and skewing towards CD21lo B cell subset, which is considered autoreactive-like, was observed in all patients. Of note, the patient had low plasmablasts, but normal immunoglobulins. Of her family members, only one was receiving both sirolimus and IgRT. Conclusion(s): We describe a rare case of COVID-19-related encephalitis in a patient with inborn error of immunity while not on IgRT. This may indicate infection susceptibility because of a lack of sufficient immunity to SARS-CoV-2, unlike the rest of her family with the same PIK3CD variant.Copyright © 2023 Elsevier Inc.

Characteristics and Clinical Implications of Anti-IFN-alpha cytokine antibodies in partial Recombinase Activating Gene Deficiency patients before and during the COVID-19 Pandemic

Introduction: With the onset of the COVID-19 pandemic, there was increased attention on anti- IFN-alpha autoantibodies and its correlation with severe clinical outcomes in a large group of patients. However, this correlation has not been extensively investigated in patients with partial Recombinase Activating Gene Deficiency (pRD) who are known to have increased prevalence of anti- IFN-alpha autoantibodies. Therefore, there is a need to assess the presence of anti- IFN-alpha antibodies in pRD patients before and after the COVID-19 pandemic and explore the relationship between anti- IFN-alpha antibody presence and clinical outcomes. Method(s): Sera was collected from the whole blood after informed consent and Enzyme-Linked Immunosorbent Assay was conducted to confirm the presence of IgG-specific anti- IFN-alpha autoantibodies. Positive samples were determined as OD values above 3 standard deviations of the healthy donor OD mean. Result(s): Our cohort included both adult (n = 13) and pediatric (n = 9) patients with variants in RAG1 and RAG2. Eleven patients (50%) out of the 22 showed elevated anti- IFN-alpha autoantibodies levels. Five patients (23%) were defined as low positive for anti- IFN-alpha autoantibodies, and 6 patients had no autoantibody titers. Of the 22 patients, 16 were symptomatic with infectious and non-infectious complications including recurrent viral and/or bacterial infections, autoimmune cytopenias, and lymphoproliferation. Ten (63%) of the symptomatic patients demonstrated high anti-IFN-alpha autoantibodies titers. Of the 11 patients with no or low neutralizing anti- IFN-alpha autoantibodies levels, 5 were asymptomatic. In temporal comparison, 16 samples were collected pre-COVID-19 pandemic;8 samples were collected during the pandemic, 2 of which belonged to patients with samples collected before and during the pandemic. In the pre-pandemic cohort, 66% had anti- IFN-alpha autoantibodies. Conversely, during the COVID-19 pandemic, 89% had anti- IFN-alpha autoantibodies. Of note, one patient who had neutralizing anti- IFN-alpha autoantibodies remained positive both before and during the pandemic despite HSCT. Patient also had a SARS-CoV-2 infection in summer of 2022 with a mild clinical course. Conclusions & Next Steps: We observed persistence of anti-IFN-alpha autoantibodies in our cohort post-pandemic and even post-HSCT. It is unclear whether the presence of anti-cytokine antibodies are risk factor for severe COVID-19.Copyright © 2023 Elsevier Inc.

Zihinsel Yetersizli?i Olan 0-18 Ya? Aras? ?ocuk ve Ad?lesanlar?n Ebeveynlerinin A??ya Kar?? Tutumlar? Attitudes of the Parents of Children and Adolescents Aged 0-18 with Intellectual Disability to Vaccine

Objective: Studies have shown that individuals with disabilities participate in routine immunization programs less than individuals without any disabilities. This study was carried out to explore the attitudes of parents of children and adolescents aged 0-18 years with an intellectual disability towards vaccination before the COVID-19 pandemic.Material and Methods: This descriptive study was conducted with the parents of 94 children and adolescents aged 0-18 years who were educated in a special training center in Izmir. Socio-demographic Questionnaire and Attitudes towards Vaccination Scale were used as data collection tools for the study. Attitudes towards Vaccine Scale has been developed by Cvjetkovic et al. Ethics approval was obtained from the Izmir Katip celebi University Non-Invasive Clinical Research Ethics Committee, and institutional approval was obtained from the institution administration. Results:The rate of parents who stated that they believed that vaccines had serious side effects was 73.4%. The rate of families who had never been vaccinated and thought that the vaccines were ineffective was 14.9%. The parents' total ATVS median score was 43 and they displayed a moderately positive attitude. Those who believed that "vaccines have serious side effects" had the lowest median ATVS score (p< 0.005). Median ATVS scores of fully vaccinated parents were higher than those of the parents who did not have any vaccinations and who had incomplete vaccination, and they displayed a more positive attitude (p< 0.005). According to the parents' sources of information, ATVS scores were compared (p< 0.005), and the median ATVS scores of those who received information from healthcare personnel were higher than those of the parents who received information from other sources (p< 0.005). Conclusion: In this study, while 14.9% of the parents of children and adolescents with intellectual disabilities reported that they did not get their children vaccinated, 85.1% got their children vaccinated. Children and adolescents with intellectual disabilities have higher health risks due to various reasons such as the inadequacy of health protection and improvement programs, and therefore, they should be among the priority groups in immunization.

Investigation of the Anxiety Level of Senior Students of the Statistics Department of the Faculty of Science in Ankara Research Universities

The university period, in which people realize, evaluate and develop themselves, is extremely important. In this process, job and future uncertainty, expectations and negative influences, especially in the last year, can cause anxiety in people. This situation also affects the learning process of individuals. The aim of this study is to determine the severity of the anxiety levels in terms of various variables of the senior statistics department students. The research covers the senior students of the statistics department of the Science Faculty at Ankara research universities in the 2020-2021 academic year. Based on Ankara, Gazi, Hacettepe and Middle East Technical Universities, the sample size of the sample to be selected was determined in equal shares and 93 samples were obtained, under the assumption that the senior students of the Statistics Department of each university had equal anxiety. "Spielberger State-Trait Anxiety Inventory" and "Beck Hopelessness Scale" were applied to the research group. The obtained data were analyzed with SPSS 28 statistical program. It has been observed that the anxiety and hopelessness levels of senior statistics department students are affected by the effects of COVID-19 on future plans, monthly income, weighted grade point average at the university, age, advantages outside the university, and work experience variables, and are not affected by the gender, marital status, number of siblings, graduated high school type, university studied, reason for choosing statistics department, pre-university settlement, parent education status, job priority, future job prospect, current job prospects, current working status, the idea of finding a suitable job time in accordance with the received education, the most appropriate strategy in case of the not employed within one year, self-development in the COVID-19 pandemic variables. As a result, it is considered that the senior students' anxiety and hopelessness should be reduced, in order to improve themselves better and more effectively providing psychological counseling and guidance services and by increasing training seminars in this direction in the education process, necessary to support them in order to cope with anxiety and hopelessness.

Attitudes of the Parents of Children and Adolescents Aged 0-18 with Intellectual Disability to Vaccine

Objective: Studies have shown that individuals with disabilities participate in routine immunization programs less than individuals without any disabilities. This study was carried out to explore the attitudes of parents of children and adolescents aged 0-18 years with an intellectual disability towards vaccination before the COVID-19 pandemic. Material(s) and Method(s): This descriptive study was conducted with the parents of 94 children and adolescents aged 0-18 years who were educated in a special training center in Izmir. Socio-demographic Questionnaire and Attitudes towards Vaccination Scale were used as data collection tools for the study. Attitudes towards Vaccine Scale has been developed by Cvjetkovic et al. Ethics approval was obtained from the Izmir Katip Celebi University Non-Invasive Clinical Research Ethics Committee, and institutional approval was obtained from the institution administration. Result(s): The rate of parents who stated that they believed that vaccines had serious side effects was 73.4%. The rate of families who had never been vaccinated and thought that the vaccines were ineffective was 14.9%. The parents' total ATVS median score was 43 and they displayed a moderately positive attitude. Those who believed that "vaccines have serious side effects" had the lowest median ATVS score (p< 0.005). Median ATVS scores of fully vaccinated parents were higher than those of the parents who did not have any vaccinations and who had incomplete vaccination, and they displayed a more positive attitude (p< 0.005). According to the parents' sources of information, ATVS scores were compared (p< 0.005), and the median ATVS scores of those who received information from healthcare personnel were higher than those of the parents who received information from other sources (p< 0.005). Conclusion(s): In this study, while 14.9% of the parents of children and adolescents with intellectual disabilities reported that they did not get their children vaccinated, 85.1% got their children vaccinated. Children and adolescents with intellectual disabilities have higher health risks due to various reasons such as the inadequacy of health protection and improvement programs, and therefore, they should be among the priority groups in immunization.Copyright © 2023 by Pediatric Infectious Diseases and Immunization Society.

Lactate and D-Dimer levels in acute pulmonary embolism and COVID-19 Lactate and D-Dimer in COVID-19

Aim: This study aimed to compare clinical data and laboratory results in patients examined for suspected pulmonary embolism (PE) in the emergency department based on three groups: patients with coronavirus disease-2019 (COVID-19), patients with PE and patients with both COVID-19 and PE. Material(s) and Method(s): This retrospective study was approved by the local ethics committee of the university. Patients included in the study were divided into three groups: Group 1, consisting of COVID-19-polymerase chain reaction (PCR) (negative) and PE (positive) patients;Group 2, consisting of COVID-19-PCR (positive) and PE (negative) patients, and Group 3, consisting of COVID-19-PCR (positive) and PE (positive) patients. Result(s): The three patient groups included in the study had no difference in terms of age (p = 0.916) or sex. The laboratory results of the groups were compared using the Kruskal-Wallis test, which showed significant differences in the levels of white blood cells (p = 0.005), lymphocytes (p < 0.001), neutrophils (p = 0.016), D-Dimer (p < 0.001) and lactate (p = 0.001). Receiver operating characteristic curve analysis with a cut-off value of >2590 for D-Dimer showed 71.43% specificity and 78% sensitivity in differentiating Group 1 from Group 2, and with a cut-off value of >3640, it had 80% specificity and 81.82% sensitivity in differentiating Group 3 from Group 2. Discussion(s): COVID-19 leads to increased incidence of PE. In addition to clinical data, D-Dimer and lactate levels can be used in the differentiation of these patients.Copyright © 2022, Derman Medical Publishing. All rights reserved.

Trimethylamine N-Oxide levels increase in patients with severe and non-severe COVID-19

Aim: This study aimed to measure and evaluate serum trimethylamine N-oxide (TMAO) levels in patients with COVID-19. Material(s) and Method(s): The patients were divided into three groups according to their polymerase chain reaction (PCR) results and the clinical picture of the disease: Group 1 (negative PCR result, n = 44), Group 2 (positive PCR result and non-severe disease, n = 38) and Group 3 (positive PCR result and severe disease, n = 45). Result(s): TMAO levels were significantly different among the three patient groups. Post Hoc Dunn's analysis revealed a significant difference between Group 1 and Group 2 (p = 0.006), Group 1 and Group 3 (p < 0.001) and Group 2 and Group 3 (p = 0.031). ROC analysis revealed that a cut-off value of 2.92 had a sensitivity of 74.70%, a specificity of 68.18%, a positive predictive value of 81.6% and a negative predictive value of 58.8%. Discussion(s): The results of this study demonstrated that TMAO levels increased in the patients with COVID-19, and further TMAO levels increased as the severity of the disease progressed.Copyright © 2023, Derman Medical Publishing. All rights reserved.

Evaluation of incidence and prognosis of COVID-19 in patients with Nasal Polyps

Objective: Coronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Type 2 immune response accompanied by type 2 cytokines such as IL-4, IL-5, IL-13, and eosinophilic inflammation, may have a potential protective effect against COVID-19 in chronic rhinosinusitis patients with nasal polyps (CRS + P). In the study, it was aimed to investigation the prevalence and prognosis of COVID-19 in chronic rhinosinusitis patients with nasal polyps (CRS + P). Materials and Methods: Patients between the ages of 15-65 operated for CRS + P and were compared with the control group in terms of incidence and disease severity. Results: Covid RT-PCR test was positive in 5.04% of CRS + P patients. This rate was 8.96% in the control group, and the difference between both groups was statistically significant. When the two groups were compared in terms of disease severity, no significant difference was found. Conclusions: The incidence of COVID-19 was lower in patients with CRS + P. However, further prospective studies are needed to research the relationship between nasal polyp and COVID-19.

Diagnosis of Covid-19 Via Patient Breath Data Using Artificial Intelligence

Using machine learning algorithms for the rapid diagnosis and detection of the COVID-19 pandemic and isolating the patients from crowded environments are very important to controlling the epidemic. This study aims to develop a point-of-care testing (POCT) system that can detect COVID-19 by detecting volatile organic compounds (VOCs) in a patient's exhaled breath using the Gradient Boosted Trees Learner Algorithm. 294 breath samples were collected from 142 patients at Istanbul Medipol Mega Hospital between December 2020 and March 2021. 84 cases out of 142 resulted in negatives, and 58 cases resulted in positives. All these breath samples have been converted into numeric values through five air sensors. 10% of the data have been used for the validation of the model, while 75% of the test data have been used for training an AI model to predict the coronavirus presence. 25% have been used for testing. The SMOTE oversampling method was used to increase the training set size and reduce the imbalance of negative and positive classes in training and test data. Different machine learning algorithms have also been tried to develop the e-nose model. The test results have suggested that the Gradient Boosting algorithm created the best model. The Gradient Boosting model provides 95% recall when predicting COVID-19 positive patients and 96% accuracy when predicting COVID-19 negative patients. © The Authors.

Context-based Biology Motivations of Secondary School Students

This study aimed to examine the motivation of secondary school students toward context-based biology in terms of variables. Motivations were examined in terms of gender, grade level, school type, project experience, and biology laboratory experience. The research was planned according to the "Survey design." The sample consisted of 545 students studying at different grade levels (9th, 10th, 11th, and 12thgrades) of secondary education institutions in Turkey. The study data were collected through the "Context-Based Biology Motivation Scale (CBBMS)". The measurement tool consists of 34 items in a five-point Likert type, and a total of three sub-factors: association and effect, participation and competence, and enjoyment and satisfaction. Cronbach's alpha reliability coefficient was determined (α = 0.943) for the entire measurement tool. For the sub-factors, it was α = 0.898 for association and effect, α = 0.914 for participation and competence, α = 0.846 and for enjoyment and satisfaction. For independent groups, the t-test, one-way analysis of variance (ANOVA), and Tukey test were used in the data analysis. According to the research results, secondary school students' motivations toward context-based biology differed significantly according to gender, school type, biology laboratory experience, and grade level. On the contrary, motivations did not differ significantly according to their project experiences. The data obtained from the research will contribute to the literature in determining the factors affecting the motivation of secondary school students toward context-based biology. © 2022 Journal of Open Humanities Data. All rights reserved.

Lactate and D-Dimer levels in acute pulmonary embolism and COVID-19

Aim: This study aimed to compare clinical data and laboratory results in patients examined for suspected pulmonary embolism (PE) in the emergency department based on three groups: patients with coronavirus disease-2019 (COVID-19), patients with PE and patients with both COVID-19 and PE.Material and Methods: This retrospective study was approved by the local ethics committee of the university. Patients included in the study were divided into three groups: Group 1, consisting of COVID-19-polymerase chain reaction (PCR) (negative) and PE (positive) patients;Group 2, consisting of COVID-19-PCR (positive) and PE (negative) patients, and Group 3, consisting of COVID-19-PCR (positive) and PE (positive) patients.Results: The three patient groups included in the study had no difference in terms of age (p = 0.916) or sex. The laboratory results of the groups were compared using the Kruskal-Wallis test, which showed significant differences in the levels of white blood cells (p = 0.005), lymphocytes (p < 0.001), neutrophils (p = 0.016), D-Dimer (p < 0.001) and lactate (p = 0.001). Receiver operating characteristic curve analysis with a cut-off value of >2590 for D-Dimer showed 71.43% specificity and 78% sensitivity in differentiating Group 1 from Group 2, and with a cut-off value of >3640, it had 80% specificity and 81.82% sensitivity in differentiating Group 3 from Group 2.Discussion: COVID-19 leads to increased incidence of PE. In addition to clinical data, D-Dimer and lactate levels can be used in the differentiation of these patients.

Comparison of Renal Cell Cancer Surgery During the COVID-19 Pandemic with Prepandemic Period, Turkey Multicenter Study

Objective: Coronavirus disease-2019 (COVID-19) pandemic changed various priorities in health area. Many elective surgeries for renal cell cancers (RCC) have been postponed. We examined the influence of the COVID-19 pandemic on the surgical treatment of RCC in Turkey. Material(s) and Method(s): Surgically treated 457 patients for kidney tumor, from March 1, 2019 to February 28, 2021 in 9 centers in Turkey were analyzed retrospectively. Result(s): The number of surgical treatments for RCC during the COVID-19 pandemic has decreased significantly, in contrast to the same period before COVID-19. Admission symptoms were similar in these two periods (p=0.32). However, although not statistically significant, the rate of admission to hospital due to hematuria was higher during the pandemic period compared to the prepandemic period (14.4% vs 9.8%, respectively). The two study periods differed significantly in terms of the rate of metastatic RCC detected in preoperative imaging (13.1% vs 6.1%, during COVID-19 and pre-COVID-19, respectively) (p=0.01). Moreover, the study periods differed significantly in terms of time between imaging and operation [35 (2-240) vs 30 (1-210) days, during COVID-19 and pre-COVID-19, respectively] (p=0.01). However, these two periods were similar in terms of tumor size, type of surgery, and pathological stage (p>=0.05). Although the pathological stages were similar among the groups, nephrectomies due to the metastatic disease were significantly higher in the pandemic period (p=0.01). Conclusion(s): The number of RCC-related surgeries were significantly decreased during the pandemic period. However, the rate of surgery for metastatic disease has significantly increased. © Copyright 2022 by Urooncology Association Bulletin of Urooncology / Published by Galenos Yayinevi 119.

Examining the training and education potential of the metaverse: Results from an empirical study of next generation SAFe training

Restrictions imposed by the COVID-19 pandemic have forced many to seek alternative means of training and learning, which ended up with increasing investment in the notion of the metaverse. Metaverse is envisioned as the next iteration of the Internet in which the virtual and the real world are blended to materialize a highly immersive experience. Not surprisingly, perhaps, next-generation training and education systems are concerned with methods to integrate themselves into metaverse environments. In particular, participants are looking for more interactive and flexible training while maintaining a degree of educational content and high quality for their training plans and interactive workflows. In this paper, we conducted research to explore the role of metaverse in employee training. To this end, we utilized a variant of PlaySAFe (i.e., a 3D game) to investigate its metaverse adoption and usage. A qualitative design was adopted, using semistructured interviews to explore practitioners' experiences using the new version of PlaySAFe. After having it played in an industrial setting, we interviewed a group of software practitioners to compare the actual and expected features. This research has explored the pros and cons of using the current technologies for the practical groundwork of SAFe training. Findings from this research suggest that the metaverse holds the potential to deliver improved practical alignment in training and education programs, but that at the present time, practitioners expect more metaverse compatible features.

The Importance of Leadership in the Time of Covid-19: The Example of Turkish Health Minister Fahrettin Koca's Youtube Shares

Leadership is an important parameter in the healthcare field. The need for a leader with digital skills in the context of social transformation and digitalization has become more important, especially during the Covid-19 pandemic. This study discusses the leadership of the Minister of Health of the Republic of Turkey, Fahrettin Koca, in the context of digital environments during the pandemic. The reason for choosing Minister Koca as the leader is that he undertook the responsibilities of informing, persuading, and guiding citizens about the Covid-19 Pandemic. Koca has impressed the citizens of the Republic of Turkey with the shares he made from digital media at regular intervals with his rhetoric, knowledge, and vision. The aim of the study is to reveal how transformational leadership in the field of health is applied in digital environments after the Covid-19 in Turkey. Press meetings held by Minister Koca were evaluated based on transformational leadership categories to raise public awareness in the digital environment. In this qualitative research, the data were obtained from the official Youtube account of Minister of Health Koca. The data were evaluated by content analysis method using the MAXQDA program. The phenomenon of digital leadership after Covid-19 was discussed through digital transformation and leadership theories. As a result of the study, it was seen that Health Minister Koca have transformational leadership capability at both individual and organizational level.

Clustering Eurozone Countries According to Employee Contributions Before and After COVID-19

Many researchers have tried to analyze economic situations with cluster analyses. In this study, we try to analyze the effects of coronavirus disease 2019 (COVID-19) on 29 Eurozone countries by changes of the clusters. The dataset contains species from the European Union formal data group, and they are gross domestic product (GDP) at current prices per hour worked, average annual hours worked per person employed, GDP at 2015 reference levels adjusted for the impact of terms of trade per person employed, real compensation per employee (deflator GDP: total economy) and real unit labor costs (total economy: ratio of compensation per employee to nominal GDP per person employed). We investigate the economic indicators of two different years independently. The cluster analysis for 2019 gives us two clusters for the 29 Eurozone countries. On the other hand, the cluster analysis with the same data group for 2020 gives three clusters. Some countries dissociate positively, while others are affected by COVID-19 negatively. The study shows that COVID-19 affected Eurozone countries in terms of certain European Union employee data group. © 2022 by World Scientific Publishing Europe Ltd.

Clinical Characteristics of COVID-19 in Active or Previously Treated Tuberculosis Patients in Turkey

Aim: There is limited literature on coronavirus disease-2019 (COVID-19) and tuberculosis (TB) coinfection, although high rates of coinfection between COVID-19 and other respiratory pathogens are expected. To the best of our knowledge, this is the first study to examine COVID-19 infection in patients diagnosed with active or previously treated TB in Turkey. In this study, the aim was to examine the frequency of COVID-19 and the factors affecting the frequency of COVID-19 in patients with active or previously treated TB. Method(s): The population of the retrospective cohort type study consisted of patients with TB enrolled in the Elazig Tuberculosis Dispensary between January 2015 and April 2021. The TB-related data of the patients was obtained from the Public Health Management System Tuberculosis System, and the COVID-19 information was obtained from the COVID-19 Case Tracking System. The status of being alive or dead and the date of death if they were dead were obtained from the Central Population Management System. Result(s): 23.92% (n=105) of 439 patients with TB were COVID-19 cases. Advanced age, having at least one comorbid disease, and the presence of chronic pulmonary disease, diabetes mellitus, and heart disease increased the risk of developing COVID-19 in active or previously treated patients with TB. Conclusion(s): COVID-19 was detected more frequently in active or previously treated TB patients than in the general population. Within the scope of public health services implemented to prevent the spread of COVID-19 infection, priority should be given to the TB patient group and older people, especially those with comorbid chronic pulmonary disease, diabetes mellitus, and heart disease in this group. Copyright © 2022 by The Medical Bulletin of Istanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayinevi.

Long-Covid: What Awaits Us after Corona Infection?

Purpose: In this study, it was aimed to investigate the symptoms (Long-Covid) that continue after 28 days and the factors affecting its formation in patients who had a mild course of Covid-19 and recovered.Material and Methods: Until July 2021, 64 thousand Covid-19 patients were diagnosed in Kutahya. A questionnaire was conducted by contacting 659 people, who did not have hospitalization indications, either face-to-face or by telephone and 635 people completed it.Results: The mean age of the patients, 50.10% of whom were women and 43.50% were university graduates, was 44.26 +/- 15.69 years. It was determined that an average of 6.39 +/- 2.61 months (min:2;max:14) had passed since the patients were diagnosed with Covid-19. The most common symptoms was fatigue followed by muscle pain, memory problems, joint pain, and loss of smell, respectively. It was found that there was a significant relationship between the presence of prolonged symptoms and the observation of symptoms at the beginning of the disease, the presence of lung involvement, the status of taking anticoagulants, and the prolongation of the recovery time of active symptoms (p<0.05). Female gender, presence of chronic disease and non-vaccination were observed at higher rates in Long-Covid patients.Conclusion: Prolonged symptoms are more common in patients with a severe clinical course of Covid-19 disease. As vaccination rates increase, the rate of observing prolonged symptoms decreases. There is a need for new research on this subject with more vaccinated individuals.

Opinions of students who have sports education in the pandemic (COVID- 19) process on synchronous distance education

Aim: In this study, our aim is to reveal the views of students who receive sports education about synchronous distance education applications.